THE BIG BANG THEORY is a comedy from the Emmy Award nominated Co-Creator and Executive Producer of "Two and a Half Men" Chuck Lorre, about brainy best friends Leonard (Johnny Galecki, "Roseanne") and Sheldon (Jim Parsons "Judging Amy"), who can tell you anything you want to know about quantum physics, but when it comes to dealing with everyday life here on earth they're lost in the cosmos.  Neither fully understands that scientific principles don't always apply in matters of the heart - until they meet their sexy new neighbor Penny (Kaley Cuoco, "8 Simple Rules..."), a friendly screenwriter/waitress from the midwest who also happens to be newly single.  She quickly makes an impression on the other members of Leonard and Sheldon's geek squad - Howard Wolowitz (Simon Helberg, "Studio 60 on the Sunset Strip"), who portrays himself as the Casanova of Cal Tech, and fellow whiz kid Rajesh Koothrappali (Kunal Nayyar, "NCIS"), who is rendered speechless around anyone unprepared to converse about the Theory of Relativity or other scientific jargon.  The chemistry between this gaggle of geniuses and a delightful damsel is about to undergo a stimulating series of inter-personal experiments.  Multiple Emmy Award winner James Burrows ("Will & Grace") directed the pilot.  Lorre and Bill Prady ("Gilmore Girls," "Dharma & Greg") are executive producers for Warner Bros. Television.